Molecular Biology for Health Sciences careers

In the IGCSE and CIE (Cambridge International Education)curricula, Genetics is a part of Biology under the broader topics of inheritance and variation. It is covered in both IGCSE Biologyand AS/A Level Biology. Below is a breakdown of what you can expect in each: IGCSE Biology (Cambridge - 0610/0970) The topic of genetics is introduced under the following key areas: 1. Variation and Inheritance - Genetic variation: Understanding differences caused by genetic and environmental factors. - Inheritance: - Definition of key terms: genes, alleles, dominant, recessive, homozygous, heterozygous, phenotype, genotype. - Monohybrid inheritance (using Punnett squares to predict offspring ratios). - Concepts of dominant and recessive traits. - Structure of DNA: - Basic structure of DNA (double helix) and its role in carrying genetic information. - Mutations: - Causes (e.g., radiation, chemicals) and effects of mutations on organisms. 2. Selective Breeding and Genetic Engineering (basic concepts): - Selective breeding in animals and plants to produce desired traits. - Introduction to genetic modification (GM), though details are limited in IGCSE. --- CIE AS and A Level Biology (9700) At the A Level, genetics is covered in greater depth. Key concepts include: 1. DNA and Protein Synthesis: - Structure of DNA, RNA, and nucleotides. - Transcription, translation, and protein synthesis. - Genetic code and its universal nature. 2. Cell Division: - Mitosis and meiosis. - Significance of meiosis in genetic variation (crossing over, independent assortment). 3. Inheritance: - Mendelian genetics: monohybrid and dihybrid crosses. - Codominance and multiple alleles. - Sex-linked inheritance (e.g., haemophilia, color blindness). - Pedigree analysis. 4. Gene Technology: - Recombinant DNA technology (genetic modification and cloning). - Applications of genetic engineering in medicine and agriculture. 5. Mutations: - Gene mutations and their effects. - Chromosomal abnormalities. 6. Variation and Selection: - Natural selection and evolution. - Role of genetic variation in populations. --- Summary - At the IGCSE level, genetics focuses on basic concepts of inheritance, variation, DNA structure, and simple Punnett square problems. - At the AS/A Level, the depth increases significantly, introducing advanced topics like meiosis, protein synthesis, genetic engineering, and natural selection.

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